姓名 周利凯

性别  男         出生年月 1985.12  职称 讲师       

学历 研究生    学位 博士    联系电话  15613979223    

主要研究方向 糖药物化学

邮箱  201910335@xttc.edu.cn   

教育经历（从本科填起）

2008.09-2010.06 | 邢台学院 | 化学 | 本科（学士） |

2010.09-2013.06 | 河北大学 | 化学 | 研究生（硕士） | 陈华

2020.09-2025.06 | 河北大学 | 化学 | 研究生（博士） | 陈华

工作经历

2013.07-2016.08 | 康龙化成（北京）新药技术有限公司 | 研究员

2016.09-2019.02 | 赛特明强医药科技有限公司 | 高级研究员

2019.03-至今    | 邢台学院 | 教师      

承担科研项目情况

2020.01 | 基于普纳替尼结构优化BCR-ABL酪氨酸激酶抑制剂的合成及活性研究 | 河北省教育厅青年项目 | 1

2023.12 | 酸枣仁生产全链条标准化体系 | 河北省教育厅重点研发计划项目 | 4

2026.01 | 吡咯并喹喔啉并氮杂糖设计、合成及抗肿瘤活性研究 | 河北省教育厅 | 1

2023.03 | 新型光引发剂有机合成路线开发 | 横向 | 1

2025.08 | 新型昆虫生长调节剂的合成 | 横向 | 1

2026.04 | 共价胺库合成 | 横向 | 1

代表性成果 

(1) Weilin Yang, Likai Zhou, Pei Zhao, Pinjiao Yang, Jilai Wu, Hua Chen*. Enamine- mediated [2+2] skeletal editing for the synthesis of eight-membered iminosugars. Organic Letters, 2026, 28, 8189-8193.

(2) Xiaoyan Huang, Yujie Niu, Chao Wei*, LiKai Zhou, Lijing Feng, Hua Chen*. Design and synthesis of fluorescent probe for determination of β-glucosidase activity and inhibitor screening. Bioorganic Chemistry, 2025, 164, 108933.

(3) Likai Zhou, Lijing Feng, Jilai Wu, Chao Wei, Hua Chen. Direct synthesis of cis-bicyclic γ-Lactam derivatives from iminosugar C-Coumarinyl glycosides. Organic Letters, 2025, 27, 5960-5964.

(4) Lijing Feng, Likai Zhou,* Weilin Yang, Xiaoyan Huang, Yuhui Liu, Jilai Wu, Chao Wei, Hua Chen*. Gold-catalyzed intramolecular coupling reduction for direct synthesis of indole-fused iminosugars. The Journal of Organic Chemistry, 2025, 90, 6816-6821.

(5) Yu Zhou, Yuan Cheng, Boyu Feng, Mei Wang, Likai Zhou,* Pingzhu Zhang, Hua Chen, and Chao Wei*. Fine-tuning of triphenylamine pyridinium salt structure: A tool for detecting organelle microenvironments. ChemistrySelect, 2025, 10, e03622.

(6) Likai Zhou, Yaxin Cui, Xiaoyan Huang, Song Xie, Jilai Wu, Chao Wei, Xiaoliu Li and Hua Chen. One-pot stereoselective synthesis of the naphthofurano-iminosugars via a [3 + 2] cycloaddition reaction. The Journal of Organic Chemistry, 2024, 89, 13235-13242.

(7) Likai Zhou, Na Ma, Jilai Wu, Weilin Yang, Lijing Feng, Song Xie, Lili Wang and Hua Chen. One-pot synthesis of hydroxylated alkaloids from sugars via a Pictet-Spengler-type reaction. Molecules, 2024, 29, 5709.

(8) Yaxin Cui, Likai Zhou, Jilai Wu, Chao Wei, Weiming Wang, Hua Chen. Lewis’s acid-promoted oxidative cleavage of carbon-carbon bonds: synthesis of N‑arylated lactam-type iminosugars. Journal of Organic Chemistry, 2024, 89, 3383–3389.

(9) Jilai Wu, Likai Zhou, Song Xie, Chao Wei, Xiaoliu Li, Hua Chen. Synthesis of 3-arylamino-2-polyhydroxyalkyl substituted indoles from unprotected saccharides and anilines. Green Chem., 2024, 26, 1883-1888.

(10) Song Xie, Jilai Wu, Likai Zhou, Chao Wei, Xiaoliu Li, Hua Chen. One-pot stereoselective synthesis of different fused multicyclic iminosugars based on the iminium-ion intermediate. Chinese Journal of Chemistry, 2024, 42, 142-150.

(11) 陈华, 周利凯, 王静, 吴琛, 王琦, 张子雨. 吡咯并喹喔啉并稠杂氮杂糖衍生物及合成方法与应用, ZL 202411530990X.